Understanding Tumour Plasticity and the Microenvironment Using Single-Cell Technologies to Identify Novel Targets for Metastatic Castration-Resistant Prostate Cancer

Grant number: 106132 | Funding period: 2021 - 2024

Completed

Abstract

Most prostate cancer patients respond well to treatment, but some develop metastatic disease and respond poorly. During metastasis the cancer spreads to multiple organs and new combinations of genes become activated, making it difficult to develop new treatments. We will investigate these patterns of activation of genes in metastatic samples and how the immune system interacts with the cancer. We will use computational models to identify new drug targets and evaluate immunotherapy as an option.

Related publications (3)

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

AS Trigos, F Bongiovanni, Y Zhang, M Zethoven, R Tothill, R Pearson, AT Papenfuss, DL Goode

2024-12-01

Background: Metazoans inherited genes from unicellular ancestors that perform essential biological processes such as cell division..

Spatial analysis with SPIAT and spaSim to characterize and simulate tissue microenvironments

Y Feng, T Yang, J Zhu, M Li, M Doyle, V Ozcoban, GT Bass, A Pizzolla, L Cain, S Weng, A Pasam, N Kocovski, YK Huang, SP Keam, TP Speed, PJ Neeson, RB Pearson, S Sandhu, DL Goode, AS Trigos

2023-12-01

Spatial proteomics technologies have revealed an underappreciated link between the location of cells in tissue microenvironments a..

Tumor immune microenvironment of primary prostate cancer with and without germline mutations in homologous recombination repair genes

AS Trigos, A Pasam, P Banks, R Wallace, C Guo, S Keam, H Thorne, C Mitchell, S Lade, D Clouston, A Hakansson, Y Liu, B Blyth, D Murphy, N Lawrentschuk, D Bolton, D Moon, P Darcy, Y Haupt, SG Williams

2022-06-01

Background Aberrations in homologous recombination repair (HRR) genes are emerging as important biomarkers for personalized treatm..

University of Melbourne Researchers

Anna Trigos